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Rie Nishi Selected Research

9-arabinofuranosylguanine

9/2014A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine.
7/2014Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line.
4/2013Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line.
2/2010A new high-performance liquid chromatography method determines low production of 9-beta-D-arabinofuranosylguanine triphosphate, an active metabolite of nelarabine, in adult T-cell leukemia cells.

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Rie Nishi Research Topics

Disease

4Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
10/2019 - 02/2010
4Leukemia
09/2014 - 09/2011
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2020 - 04/2011
2Myeloid Leukemia (Leukemia, Myelocytic)
10/2014 - 04/2014
2Hyperuricemia
01/2013 - 01/2011
2Neoplasms (Cancer)
02/2010 - 11/2006
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
07/2021
1Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
02/2010
1Hematologic Neoplasms (Hematological Malignancy)
11/2006

Drug/Important Bio-Agent (IBA)

4Cytarabine (Cytosar-U)FDA LinkGeneric
10/2020 - 04/2011
49-arabinofuranosylguanineIBA
09/2014 - 02/2010
3Clofarabine (Clolar)FDA Link
10/2020 - 09/2011
3Pharmaceutical PreparationsIBA
10/2020 - 11/2006
3nelarabine (506U78)FDA Link
10/2019 - 02/2010
3triphosphoric acid (triphosphate)IBA
09/2011 - 11/2006
2Uric Acid (Urate)IBA
01/2013 - 01/2011
110-propargyl-10-deazaaminopterinFDA Link
07/2021
1Folic Acid AntagonistsIBA
07/2021
1alvocidib (flavopiridol)IBA
10/2020
1venetoclaxIBA
10/2020
1Biomarkers (Surrogate Marker)IBA
10/2019
1olaparibIBA
10/2014
1Gemtuzumab (Mylotarg)FDA Link
10/2014
1forodesineIBA
09/2014
1Purine-Nucleoside PhosphorylaseIBA
09/2014
1YC137IBA
04/2013
1Arabinofuranosylcytosine TriphosphateIBA
04/2013
12-fluoro-araATPIBA
09/2011
1BenzbromaroneIBA
01/2011
19-beta-D-arabinofuranosylguanosine 5'-triphosphateIBA
02/2010
1DNA (Deoxyribonucleic Acid)IBA
11/2006
1GemcitabineFDA Link
11/2006
1gemcitabine triphosphateIBA
11/2006
1DeoxycytidineIBA
11/2006

Therapy/Procedure

2Therapeutics
10/2019 - 01/2013